Steroidal esters from Ferula sinkiangensis

Fitoterapia. 2014 Sep:97:247-52. doi: 10.1016/j.fitote.2014.06.016. Epub 2014 Jun 28.

Abstract

Two new steroidal esters with an unusual framework, Sinkiangenorin A and B, a new organic acid glycoside, Sinkiangenorin C, and four known lignin compounds were isolated from the seeds of Ferula sinkiangensis. The structures of these compounds were established by spectroscopic analysis and single-crystal X-ray diffraction. All of the isolated compounds were tested against Hela, K562 and AGS human cancer cell lines. Sinkiangenorin C showed cytotoxic activity against AGS cells with an IC50 of 36.9 μM.

Keywords: Arctigenin (PubChem CID: 64981); Cytotoxic activities; Ferula sinkiangensis; Lariciresinol (PubChem CID: 332427); Lignin compounds; Matairesinol (PubChem CID: 119205); Organic acid glycoside; Secroisolariciresinol (PubChem CID: 6336781); Steroidal esters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Drug Screening Assays, Antitumor
  • Esters
  • Ferula / chemistry*
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • HeLa Cells
  • Humans
  • K562 Cells
  • Molecular Structure
  • Pentanoic Acids / chemistry
  • Pentanoic Acids / isolation & purification*
  • Phytosterols / chemistry
  • Phytosterols / isolation & purification
  • Seeds / chemistry

Substances

  • 2-(1-hydroxyethyl)-4-methylpentanoic acid-4-O-glucopyranoside
  • Esters
  • Glucosides
  • Pentanoic Acids
  • Phytosterols