Two diterpenoids and a cyclopenta[c]pyridine derivative from roots of Salvia digitaloids

Shwu-Jen Wu; Chieh-Hung Huang; Yu-Yi Chan; Yu-Ren Liao; Tsong-Long Hwang; Tian-Shung Wu

doi:10.3390/ijms150711566

Two diterpenoids and a cyclopenta[c]pyridine derivative from roots of Salvia digitaloids

Int J Mol Sci. 2014 Jun 27;15(7):11566-77. doi: 10.3390/ijms150711566.

Authors

Shwu-Jen Wu¹, Chieh-Hung Huang², Yu-Yi Chan³, Yu-Ren Liao⁴, Tsong-Long Hwang⁵, Tian-Shung Wu⁶

Affiliations

¹ Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan 717, Taiwan. shwu01054@yahoo.com.tw.
² Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. hjh2000.tw@gmail.com.
³ Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 710, Taiwan. yuyichan@mail.stust.edu.tw.
⁴ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. truthloveroy@yahoo.com.tw.
⁵ Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. htl@mail.cgu.edu.tw.
⁶ Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan. tswu@mail.ncku.edu.tw.

Abstract

Two new glucosides, salviadigitoside A (1) and salviatalin A-19-O-β-glucoside (2), belonging to the salviatalin type diterpenoids, and a new cyclopenta[c]pyridine, salviadiginine A (3), were isolated from the roots of Salvia digitaloids. Structures of these compounds were determined on the basis of spectroscopic analysis. In addition, compounds 1-3 were evaluated for their anti-inflammatory activity, but the results showed a weak anti-inflammatory activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Anti-Inflammatory Agents / chemistry*
Anti-Inflammatory Agents / pharmacology
Diterpenes / chemistry*
Diterpenes / pharmacology
Glucosides / chemistry*
Glucosides / pharmacology
Humans
Neutrophils / drug effects
Plant Extracts / chemistry*
Plant Extracts / pharmacology
Plant Roots / chemistry
Salvia / chemistry*

Substances

Anti-Inflammatory Agents
Diterpenes
Glucosides
Plant Extracts