Optically induced resonance of nanoparticle-loaded microbubbles

Opt Lett. 2014 Jul 1;39(13):3732-5. doi: 10.1364/OL.39.003732.

Abstract

We report on the optical excitation and detection of resonant microbubble oscillations. Optically absorbing nanoparticles were attached to the shell of a lipid-encapsulated microbubble, allowing for optical pulsing to photothermally drive the microbubble into resonance. A modified optical microscope was used to track the bubble wall radius as a function of time using light scattering. The microbubble response from a nanosecond laser pulse was measured, and the eigenfrequency and vibrational amplitude were determined and compared to theory. The ability to optically drive microbubble oscillations may have applications in basic studies of bubble dynamics and biomedical imaging and therapy.

MeSH terms

  • Coated Materials, Biocompatible
  • Contrast Media
  • Gold
  • Lasers
  • Metal Nanoparticles* / ultrastructure
  • Microbubbles*
  • Microscopy, Acoustic / instrumentation
  • Optical Phenomena
  • Particle Size
  • Photoacoustic Techniques / instrumentation

Substances

  • Coated Materials, Biocompatible
  • Contrast Media
  • Gold