Flavanones from Miconia prasina

Amer H Tarawneh; Francisco León; Mohammed A Ibrahim; Sara Pettaway; Christopher R McCurdy; Stephen J Cutler

doi:10.1016/j.phytol.2013.11.001

Flavanones from Miconia prasina

Phytochem Lett. 2014 Feb:7:130-132. doi: 10.1016/j.phytol.2013.11.001.

Authors

Amer H Tarawneh¹, Francisco León¹, Mohammed A Ibrahim², Sara Pettaway¹, Christopher R McCurdy³, Stephen J Cutler³

Affiliations

¹ Department of Medicinal Chemistry, The University of Mississippi, University, MS 38677, USA.
² National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.
³ Department of Medicinal Chemistry, The University of Mississippi, University, MS 38677, USA ; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

Abstract

A glycosidic flavanone miconioside C (1) has been isolated from the methanolic extract of the stems of Miconia prasina, together with 7-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranosylmatteucinol (2), miconioside B (3), matteucinol (4), farrerol (5) and desmethoxymatteucinol (6). Their structures were mainly established by extensive NMR studies (¹H NMR, ¹³C NMR, DEPT, ¹H-¹H COSY, HSQC, HMBC) and mass spectrometry. The compounds 1- 3 were evaluated for in vitro binding assays using cannabinoid receptors (CB1 and CB2).

Keywords: Melastomataceae; Miconia prasina; cannabinoids receptors; flavanone; flavanone glycoside.

Abstract

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