Add neurons, subtract anxiety

Sci Am. 2014 Jul;311(1):62-7. doi: 10.1038/scientificamerican0714-62.

Abstract

To keep memories from becoming jumbled, the brain must encode the distinct features of events and situations in a way that allows them to be distinguished from one another—a process called pattern separation.

Pattern separation enables us to distinguish dangerous situations from similar ones that pose no risk. People with defects in this ability may be prone to anxiety disorders.

The process occurs in one of the two regions of the brain that generate neurons throughout life. These fledgling cells seem to be critical to pattern separation.

Interventions that specifically boost the ranks of rookie neurons could provide new ways to regulate mood and possibly treat conditions such as post-traumatic stress disorder.

MeSH terms

  • Animals
  • Antidepressive Agents, Second-Generation
  • Anxiety Disorders / physiopathology
  • Anxiety Disorders / therapy*
  • Dentate Gyrus / physiology
  • Fluoxetine / pharmacology
  • Hippocampus / cytology
  • Humans
  • Memory / physiology
  • Neurogenesis / physiology*
  • Neurons / physiology*
  • Pattern Recognition, Physiological

Substances

  • Antidepressive Agents, Second-Generation
  • Fluoxetine