Triterpenoids with anti-tobacco mosaic virus activities from Melia toosendan

Fitoterapia. 2014 Sep:97:204-10. doi: 10.1016/j.fitote.2014.06.010. Epub 2014 Jun 24.

Abstract

Four new triterpenoids, named Toosendansins A-D (1-4), along with nine known ones (5-13) were isolated from the fruits of Melia toosendan Sieb. et Zucc. Their structures were established on the basis of spectroscopic data. The isolation of compounds 1-12 were reported for the first time from this plant. All compounds were analyzed for the anti-Tobacco Mosaic Virus (TMV) activity and protective effect on H2O2-induced damage of SH-SY5Y cells. Compound 7 showed evident anti-TMV activity. Compounds 2 and 9 exhibited modest protection against H2O2-induced damage of SH-SY5Y cells.

Keywords: Anti-tobacco mosaic virus activities; Limonoids; Melia toosendan; Triterpenoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / isolation & purification
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Cell Line
  • Humans
  • Limonins / chemistry
  • Limonins / isolation & purification*
  • Limonins / pharmacology
  • Melia / chemistry*
  • Microbial Sensitivity Tests
  • Tobacco Mosaic Virus / drug effects*
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology

Substances

  • Antioxidants
  • Antiviral Agents
  • Limonins
  • Triterpenes