Abstract
The IgG subclass distribution to the E34/E32 peptides, derived from the HIV-1 glycoprotein 41 transmembrane protein, was analyzed in ELISA. Sera from individuals at different stages of the disease were assayed. A restricted subclass response of mainly IgG1 and IgG2 was found. The subclass response was of a different type than the one observed to HIV whole Ag and to a synthetic peptide from the C'-terminal part of the HIV-1 p24 core protein. An increased subclass restriction was observed in progressed stages of the disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acids / metabolism
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Antibody Specificity
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Binding Sites, Antibody
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HIV Antibodies / biosynthesis*
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HIV Antibodies / classification
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HIV Antigens / immunology*
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HIV Core Protein p24
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HIV Envelope Protein gp41
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HIV-1 / immunology*
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HIV-1 / metabolism
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Humans
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Immunoglobulin G / biosynthesis
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Immunoglobulin G / classification*
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Immunoglobulin G / metabolism
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Membrane Proteins / immunology*
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Membrane Proteins / metabolism
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Molecular Sequence Data
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Peptides / immunology
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Peptides / metabolism
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Retroviridae Proteins / immunology
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Viral Envelope Proteins / immunology*
Substances
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Amino Acids
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HIV Antibodies
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HIV Antigens
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HIV Core Protein p24
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HIV Envelope Protein gp41
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Immunoglobulin G
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Membrane Proteins
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Peptides
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Retroviridae Proteins
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Viral Envelope Proteins