Abstract
The paper describes a new pathway for an efficient synthesis of natural and bioactive drimanic compounds ( - )-pereniporin B (1) and ( - )-cinnamosmolide (2) from ketodiol 7, an intermediate obtained before from accessible labdane diterpenoid (+)-larixol (3). The key step involves allylic bromination of acetate 8 with N-bromosuccinimide. The in vitro antimicrobial and antifungal activities of all compounds are also reported. Their structures were confirmed by both spectroscopic data and chemical transformations.
Keywords:
(+)-larixol; ( − )-cinnamosmolide; ( − )-pereniporin B; formal synthesis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Diterpenes / chemistry
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Diterpenes / isolation & purification
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Sesquiterpenes / chemical synthesis*
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Sesquiterpenes / chemistry
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Sesquiterpenes / pharmacology
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Stereoisomerism
Substances
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Antifungal Agents
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Antineoplastic Agents
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Diterpenes
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Sesquiterpenes
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cinnamosmolide
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labdane
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larixol
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pereniporin B