Induction of apoptosis by a peptide from Porphyra yezoensis: regulation of the insulin-like growth factor I receptor signaling pathway in MCF-7 cells

Int J Oncol. 2014 Sep;45(3):1011-6. doi: 10.3892/ijo.2014.2509. Epub 2014 Jun 20.

Abstract

This study examined how PPY, a peptide from Porphyra yezoensis, regulates multiple cell growth-related signaling pathways in MCF-7 cells. This study determined that PPY induces cell cycle arrest and inhibits the IGF-IR signaling pathway. Cell proliferation studies revealed that PPY induced cell death in a dose-dependent manner. Expression levels of IGF-IR were decreased in MCF-7 cells by PPY in a dose‑dependent manner. These results indicate that inhibition of the IGF-IR pathway is also involved in PPY induced proliferation of MCF-7 cells. In addition, these data demonstrated that PPY induces cell cycle arrest and activates apoptosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis*
  • Breast Neoplasms / drug therapy*
  • Breast Neoplasms / metabolism
  • Cell Cycle / drug effects
  • Cell Cycle Checkpoints
  • Dose-Response Relationship, Drug
  • Female
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • MCF-7 Cells
  • Peptides / chemical synthesis
  • Peptides / pharmacology*
  • Plant Proteins / pharmacology*
  • Porphyra / chemistry*
  • Signal Transduction / drug effects

Substances

  • PPY peptide, Porphyra yezoensis
  • Peptides
  • Plant Proteins