Epstein-Barr virus induced hemophagocytic lymphohistiocytosis in X-linked lymphoproliferative disease

Senthilkumar Sankararaman; Rosario Maria Riel-Romero; Majed Jeroudi; Eduardo Gonzalez-Toledo

doi:10.4103/0976-3147.131669

Epstein-Barr virus induced hemophagocytic lymphohistiocytosis in X-linked lymphoproliferative disease

J Neurosci Rural Pract. 2014 Apr;5(2):171-4. doi: 10.4103/0976-3147.131669.

Authors

Senthilkumar Sankararaman¹, Rosario Maria Riel-Romero², Majed Jeroudi³, Eduardo Gonzalez-Toledo⁴

Affiliations

¹ Department of Pediatrics, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA.
² Department of Pediatrics and Neurology, Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA.
³ Department of Pediatrics (Pediatric Hematology-Oncology Division), Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA.
⁴ Department of Radiology (Neuroradiology Division), Louisiana State University Health Sciences Center, 1501 Kings Highway, Shreveport, LA, USA.

Abstract

X-linked lymphoproliferative disease (XLP) is a rare, often fatal genetic disorder characterized by extreme vulnerability to Epstein-Barr virus (EBV). EBV-induced hemophagocytic lymphohistiocytosis (HLH) is a known presentation in XLP. In EBV-induced HLH in XLP, the brain imaging findings in the acute phase include a non specific pattern. In this report, we highlight the magnetic resonance imaging and magnetic resonance spectroscopy findings in a child with EBV induced HLH in XLP.

Keywords: Epstein-Barr virus; X-linked lymphoproliferative disease; hemophagocytic lymphohistiocytosis.

Publication types

Case Reports