Abstract
We report the intermolecular palladium-catalyzed reaction of tert-butyl propargyl carbonate with tryptamine derivatives or other indole-containing bis-nucleophiles. The reaction proceeds under mild conditions and with low catalyst loadings to afford novel spiroindolenine products in good to high yields.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alkynes / chemistry*
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Carbonates / chemistry*
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Catalysis
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Combinatorial Chemistry Techniques
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Indoles / chemical synthesis*
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Indoles / chemistry
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Molecular Structure
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Palladium / chemistry*
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Spiro Compounds / chemical synthesis*
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Spiro Compounds / chemistry
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Stereoisomerism
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Tryptamines / chemistry*
Substances
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Alkynes
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Carbonates
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Indoles
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Spiro Compounds
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Tryptamines
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Palladium