Application of gas chromatography-mass spectrometry in analyzing pharmacokinetics and distribution of deltamethrin in miniature pig tissues

Biomed Environ Sci. 2014 Jun;27(6):426-35. doi: 10.3967/bes2014.035.

Abstract

Objective: To characterize the pharmacokinetics and distribution profiles of deltamethrin in miniature pig tissues by gas chromatography-mass spectrometry (GC-MS).

Methods: Pharmacokinetics and distribution of deltamethrin in blood and tissues of 30 miniature pigs were studied by GC-MS after oral administration of deltamethrin (5 mg/kg bw). Data were processed by 3P97 software.

Results: The serum deltamethrin level was significantly lower in tissues than in blood of miniature pigs. The AUC0-72 h, Cmax, of deltamethrin were 555.330 ± 316.987 ng h/mL and 17.861 ± 11.129 ng/mL, respectively. The Tmax, of deltamethrin was 6.004 ± 3.131 h.

Conclusion: The metabolism of deltamethrin in miniature pigs is fit for a one-compartment model with a weighting function of 1/C2. Deltamethrin is rapidly hydrolyzed and accumulated in miniature pig tissues.

Keywords: Deltamethrin; GC-MS; Miniature pig; Pharmacokinetics; Tissue distribution.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Animals
  • Gas Chromatography-Mass Spectrometry
  • Models, Animal
  • Nitriles / pharmacokinetics*
  • Pyrethrins / pharmacokinetics*
  • Swine
  • Swine, Miniature
  • Tissue Distribution

Substances

  • Nitriles
  • Pyrethrins
  • decamethrin