Abstract
Two new cytochalsians, multirostratin A (1) and 20-oxo-deoxaphomin (2), together with five known analogues (3-7), were obtained from the endophytic fungus Phoma multirostrata EA-12. The structures of 1 and 2 were elucidated by MS and 1D- and 2D-NMR spectroscopic data analyses, as well as by comparison of data with those of analogues reported in the literature. Compounds 1 and 2 showed moderate cytotoxicity against five tumor cell lines (HL-60, A-549, SMMC-7721, MCF-7 and SW-480).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology*
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Ascomycota / metabolism*
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Cell Line, Tumor
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Cytochalasins / chemistry
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Cytochalasins / isolation & purification
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Cytochalasins / pharmacology*
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Humans
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Magnetic Resonance Spectroscopy / methods
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Mass Spectrometry / methods
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Neoplasms / drug therapy*
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Neoplasms / pathology
Substances
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Antineoplastic Agents
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Cytochalasins