Metabolomics for secondary metabolite research

Rainer Breitling; Ana Ceniceros; Andris Jankevics; Eriko Takano

doi:10.3390/metabo3041076

Metabolomics for secondary metabolite research

Metabolites. 2013 Nov 11;3(4):1076-83. doi: 10.3390/metabo3041076.

Authors

Rainer Breitling¹, Ana Ceniceros², Andris Jankevics³, Eriko Takano⁴

Affiliations

¹ Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. rainer.breitling@manchester.ac.uk.
² Microbial Physiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Nijenborg 7, Groningen 9747 AG, The Netherlands. a.ceniceros@rug.nl.
³ Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. andris.jankevics@manchester.ac.uk.
⁴ Manchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, UK. eriko.takano@manchester.ac.uk.

Abstract

Metabolomics, the global characterization of metabolite profiles, is becoming an increasingly powerful tool for research on secondary metabolite discovery and production. In this review we discuss examples of recent technological advances and biological applications of metabolomics in the search for chemical novelty and the engineered production of bioactive secondary metabolites.