Abstract
Positron emission tomography has emerged as the leading method for medical imaging with fluorine-18 as the most widely used radioactive isotope. Here we report a semi-automated method for the preparation of valuable [(18) F]trifluoromethylcopper, as well as its use for the radiosynthesis of [(18) F]trifluoromethylarenes and heteroarenes. Mild conditions of [(18) F]trifluoromethylation make this method particularly useful for the radiosynthesis of pharmacologically relevant [(18) F]trifluoromethylarenes and heteroarenes.
Keywords:
arylboronic acid; copper; fluorine; radiochemistry; trifluoromethylation.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylating Agents / chemistry
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Boronic Acids / chemical synthesis*
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Chlorofluorocarbons, Methane / chemistry
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Copper / chemistry*
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Crystallography, X-Ray
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Fluorine Radioisotopes / chemistry*
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Hydrocarbons, Iodinated / chemical synthesis*
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Hydrocarbons, Iodinated / chemistry
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Isotope Labeling / methods
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Methylation
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Models, Molecular
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Molecular Structure
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Organometallic Compounds / chemical synthesis*
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Positron-Emission Tomography / methods
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Radiopharmaceuticals / chemical synthesis*
Substances
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Alkylating Agents
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Boronic Acids
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Chlorofluorocarbons, Methane
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Fluorine Radioisotopes
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Hydrocarbons, Iodinated
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Organometallic Compounds
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Radiopharmaceuticals
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Copper
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fluoroform