Apotirucallane protolimonoids from the Chinese mangrove Xylocarpus granatum Koenig

Fitoterapia. 2014 Sep:97:192-7. doi: 10.1016/j.fitote.2014.06.009. Epub 2014 Jun 21.

Abstract

A series of previously unreported compounds including seven new apotirucallane protolimonoids, xylogranatumines A-G (1-7), were isolated together with three known analogues (8-10) from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. The structures of these new compounds were elucidated by extensive spectroscopic analysis including 1D and 2D NMR and high-resolution electrospray ionization mass spectrometry (HRESIMS) and by comparison with those of related known compounds in the literature. Xylogranatumine F (6) exhibited cytotoxic activity against A549 tumor cell in vitro.

Keywords: Apotirucallane; Cytotoxicity; Protolimonoid; Xylocarpus granatum.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Drug Screening Assays, Antitumor
  • Humans
  • Meliaceae / chemistry*
  • Molecular Structure
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*

Substances

  • Triterpenes
  • xylogranatumine F