A one-pot parallel reductive amination of aldehydes with heteroaromatic amines

Andrey V Bogolubsky; Yurii S Moroz; Pavel K Mykhailiuk; Dmitriy M Panov; Sergey E Pipko; Anzhelika I Konovets; Andrey Tolmachev

doi:10.1021/co5000568

A one-pot parallel reductive amination of aldehydes with heteroaromatic amines

ACS Comb Sci. 2014 Aug 11;16(8):375-80. doi: 10.1021/co5000568. Epub 2014 Jul 10.

Authors

Andrey V Bogolubsky¹, Yurii S Moroz, Pavel K Mykhailiuk, Dmitriy M Panov, Sergey E Pipko, Anzhelika I Konovets, Andrey Tolmachev

Affiliation

¹ Enamine Ltd. , 23 Matrosova Street, Kyiv 01103, Ukraine.

PMID: 24956115
DOI: 10.1021/co5000568

Abstract

A parallel reductive amination of heteroaromatic amines has been performed using a combination of ZnCl2-TMSOAc (activating agents) and NaBH(OAc)3 (reducing agent). A library of diverse secondary amines was easily prepared on a 50-300 mg scale.

MeSH terms

Aldehydes / chemical synthesis
Aldehydes / chemistry*
Amination
Amines / chemical synthesis*
Amines / chemistry
Chlorides / chemistry
Combinatorial Chemistry Techniques
Hydrocarbons, Aromatic / chemical synthesis*
Hydrocarbons, Aromatic / chemistry
Oxidation-Reduction
Reducing Agents / chemistry
Small Molecule Libraries / chemical synthesis*
Small Molecule Libraries / chemistry
Zinc Compounds / chemistry

Substances

Aldehydes
Amines
Chlorides
Hydrocarbons, Aromatic
Reducing Agents
Small Molecule Libraries
Zinc Compounds
zinc chloride