Recombinant human bone morphogenetic protein-2 in debridement and impacted bone graft for the treatment of femoral head osteonecrosis

PLoS One. 2014 Jun 23;9(6):e100424. doi: 10.1371/journal.pone.0100424. eCollection 2014.

Abstract

The purpose of this study was to compare the clinical outcomes of impacted bone graft with or without recombinant human bone morphogenetic protein-2 (rhBMP-2) for osteonecrosis of the femoral head (ONFH). We examined the effect of bone-grafting through a window at the femoral head-neck junction, known as the "light bulb" approach, for the treatment of ONFH with a combination of artificial bone (Novobone) mixed with or without rhBMP-2. A total of 42 patients (72 hips) were followed-up from 5 to 7.67 years (average of 6.1 years). The patients with and without BMP were the first group (IBG+rhBMP-2) and the second group (IBG), respectively. The clinical effectiveness was evaluated by Harris hip score (HHS). The radiographic follow-up was evaluated by pre-and postoperative X-ray and CT scan. Excellent, good, and fair functions were obtained in 36, 12, and 7 hips, respectively. The survival rate was 81.8% and 71.8% in the first and second group, respectively. However, the survival rate was 90.3% in ARCO stage IIb, c, and only 34.6% in ARCO stage IIIa (P<0.05). It was concluded that good and excellent mid-term follow-up could be achieved in selected patients with ONFH treated with impacted bone graft operation. The rhBMP-2 might improve the clinical efficacy and quality of bone repair.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bone Morphogenetic Protein 2 / therapeutic use*
  • Bone Transplantation / methods*
  • Debridement*
  • Female
  • Femur Head Necrosis / mortality
  • Femur Head Necrosis / therapy*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Osteonecrosis / mortality
  • Osteonecrosis / therapy*
  • Prognosis
  • Recombinant Proteins / therapeutic use
  • Retrospective Studies
  • Survival Rate
  • Tomography, X-Ray Computed
  • Transforming Growth Factor beta / therapeutic use*
  • Young Adult

Substances

  • Bone Morphogenetic Protein 2
  • Recombinant Proteins
  • Transforming Growth Factor beta
  • recombinant human bone morphogenetic protein-2

Grants and funding

This study was supported by the National Natural Science Foundation of China (81372013) and the Research Fund of China-Japan Friendship Hospital (2013-MS-27). China-Japan Friendship Hospital Youth Science and technology excellence project (2014-QNYC-A-06). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.