Role of total hip replacement arthroplasty between transplantation and acute kidney injury

Ren Fail. 2014 Jul;36(6):899-903. doi: 10.3109/0886022X.2014.900387.

Abstract

Osteonecrosis of the femoral head is a severely disabling complication of steroid immunosuppression in renal transplant patients. The increased number of patients undergoing transplantation has increased the number of transplant recipients undergoing total hip replacement arthroplasty (THRA). In this study, we retrospectively assessed patients who underwent THRA from May 2004 to February 2014, and evaluated their demographic and clinical characteristics, the results of peri-operative laboratory tests, the amounts of fluids transfused during surgery, and anesthesia time. Our results found that post-operative acute kidney injury (AKI) was significantly associated with transplantation, and transplantation was an independent factor predictive of post-operative AKI, so transplant recipients are at risk for AKI following THRA. Total hip replacement is a safe and effective treatment for transplant recipients and, in view of their limited life expectancy, should be considered at an early stage in their treatment.

Keywords: AKI; AVN; THRA; recipients; transplantation.

MeSH terms

  • Acute Kidney Injury / etiology*
  • Adrenal Cortex Hormones / adverse effects
  • Adult
  • Aged
  • Arthroplasty, Replacement, Hip / adverse effects*
  • Femur Head Necrosis / chemically induced
  • Femur Head Necrosis / surgery
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Middle Aged
  • Organ Transplantation / adverse effects*
  • Postoperative Complications / etiology*
  • Retrospective Studies

Substances

  • Adrenal Cortex Hormones
  • Immunosuppressive Agents