A small focused library which comprised of l-AA lactone derivatives was built with a facile method. This reported method was optimized by modifying the acidity of the solvent. As a result, 12 l-AA lactones were synthesized. Among these lactones, lactones 8-12 were new compounds. The cytotoxicity of these synthetic compounds were investigated.
Keywords: Cytotoxicity; Focused library; l-Ascorbic acid lactone.