Aim: To explore the relationship of plasma osteopontin (OPN) level and renal function with severity of coronary artery lesions.
Methods: OPN level and renal function were detected and compared in 210 patients with coronary heart disease (CHD group) and 134 patients without coronary heart disease (control group) to analyze the relationship of osteopontin and renal function with severity of coronary artery lesions.
Results: Plasma OPN and creatinine level were significantly higher in CHD group than those in control group (P<0.01), and estimated glomerular filtration rate (eGFR) was lower in CHD group than that in control group (P<0.01). The proportions of multi-vessel lesion and moderate to severe decreased renal function were higher in patients with high osteopontin than those in patients with low osteopontin (P<0.05), and the proportion of multi-vessel lesion was higher in patients with moderate to severe decreased renal function than that in normal renal function (P<0.05). Osteopontin and renal failure were the independent risk factors for coronary heart disease.
Conclusions: Plasma OPN level is associated with renal failure, both of which are correlated with the severity of coronary artery lesions.
Keywords: Osteopontin; atherosclerosis; coronary heart disease; renal failure.