Abstract
Two new C-21 steroidal glycosides, dregeosides D (1) and E (2), were isolated from the roots of Dregea sinensis. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and HR-ESI-MS analysis. Finally, the inhibited effects of the isolated compounds on interleukin 2 receptor were evaluated by enzyme-linked immunosorbent assay.
Keywords:
Asclepiadaceae; Dregea sinensis; interleukin 2 receptor; steroidal glycosides.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Apocynaceae / chemistry
-
Drugs, Chinese Herbal / chemistry
-
Drugs, Chinese Herbal / isolation & purification*
-
Drugs, Chinese Herbal / pharmacology
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
Medicine, Traditional
-
Molecular Structure
-
Plant Roots / chemistry
-
Receptors, Interleukin-2 / drug effects
-
Steroids / chemistry
-
Steroids / isolation & purification*
-
Steroids / pharmacology
Substances
-
Drugs, Chinese Herbal
-
Glycosides
-
Receptors, Interleukin-2
-
Steroids
-
dregeoside D
-
dregeoside E