C-21 steroidal glycosides from Dregea sinensis

J Asian Nat Prod Res. 2014;16(8):836-40. doi: 10.1080/10286020.2014.921910. Epub 2014 Jun 23.

Abstract

Two new C-21 steroidal glycosides, dregeosides D (1) and E (2), were isolated from the roots of Dregea sinensis. The structures of the isolated compounds were elucidated on the basis of 1D and 2D NMR spectra and HR-ESI-MS analysis. Finally, the inhibited effects of the isolated compounds on interleukin 2 receptor were evaluated by enzyme-linked immunosorbent assay.

Keywords: Asclepiadaceae; Dregea sinensis; interleukin 2 receptor; steroidal glycosides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apocynaceae / chemistry
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Medicine, Traditional
  • Molecular Structure
  • Plant Roots / chemistry
  • Receptors, Interleukin-2 / drug effects
  • Steroids / chemistry
  • Steroids / isolation & purification*
  • Steroids / pharmacology

Substances

  • Drugs, Chinese Herbal
  • Glycosides
  • Receptors, Interleukin-2
  • Steroids
  • dregeoside D
  • dregeoside E