Crosstalk between DNA repair and cancer stem cell (CSC) associated intracellular pathways

Semin Cancer Biol. 2015 Apr:31:36-42. doi: 10.1016/j.semcancer.2014.06.002. Epub 2014 Jun 17.

Abstract

DNA damaging agents (ionizing radiation and chemotherapeutics) are considered as most effective in cancer treatment. However, there is a subpopulation of carcinoma cells within the tumour demonstrating resistance to DNA damaging treatment approaches. It is suggested that limited tumour response to this kind of therapy can be associated with specific molecular properties of carcinoma stem cells (CSCs) representing the most refractory cell subpopulation. This review article presents novel data about molecular features of CSCs underlying DNA damage response and related intracellular signalling.

Keywords: Ape1/Ref-1; Cancer stem cells; DNA repair; Intracellular signalling; MRN complex.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • DNA Damage*
  • DNA Repair*
  • DNA-(Apurinic or Apyrimidinic Site) Lyase / genetics
  • DNA-(Apurinic or Apyrimidinic Site) Lyase / metabolism
  • Gene Expression Regulation, Neoplastic / drug effects
  • Humans
  • Models, Genetic
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplastic Stem Cells / drug effects
  • Neoplastic Stem Cells / metabolism*
  • Neoplastic Stem Cells / pathology
  • Signal Transduction / drug effects
  • Signal Transduction / genetics*

Substances

  • Antineoplastic Agents
  • APEX1 protein, human
  • DNA-(Apurinic or Apyrimidinic Site) Lyase