Tetrahedron DNA dendrimers and their encapsulation of gold nanoparticles

Tao Zhou; Yijie Wang; Yuanchen Dong; Chun Chen; Dongsheng Liu; Zhongqiang Yang

doi:10.1016/j.bmc.2014.05.062

Tetrahedron DNA dendrimers and their encapsulation of gold nanoparticles

Bioorg Med Chem. 2014 Aug 15;22(16):4391-4. doi: 10.1016/j.bmc.2014.05.062. Epub 2014 Jun 5.

Authors

Tao Zhou¹, Yijie Wang¹, Yuanchen Dong¹, Chun Chen¹, Dongsheng Liu¹, Zhongqiang Yang²

Affiliations

¹ Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China.
² Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, China. Electronic address: zyang@tsinghua.edu.cn.

PMID: 24953949
DOI: 10.1016/j.bmc.2014.05.062

Abstract

DNA dendrimers have achieved increasing attention recently. Previously reported DNA dendrimers used Y-DNA as monomers. Tetrahedron DNA is a rigid tetrahedral cage made of DNA. Herein, we use tetrahedron DNA as monomers to prepare tetrahedron DNA dendrimers. The prepared tetrahedron DNA dendrimers have larger size compared with those made of Y-DNA. In addition, thanks to the central cavity of tetrahedron DNA monomers, some nanoscale structures (e.g., gold nanoparticles) can be encapsulated within tetrahedron DNA monomers. Tetrahedron DNA encapsulated with gold nanoparticles can be further assembled into dendrimers, guiding gold nanoparticles into clusters.

Keywords: DNA dendrimer; Encapsulation; Gold nanoparticle; Self-assembly; Tetrahedron.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

DNA / chemistry*
Dendrimers / chemistry*
Gold / chemistry*
Metal Nanoparticles / chemistry*

Substances

Dendrimers
Gold
DNA