Integrins LFA-1 and Mac-1 and cytokines IL-6 and IL-10 in high-cancer mice under the influence of phytoadaptogen

O A Bocharova; E V Bocharov; R V Karpova; V A Il'enko; I V Kazeev; A Yu Baryshnikov

doi:10.1007/s10517-014-2539-4

Integrins LFA-1 and Mac-1 and cytokines IL-6 and IL-10 in high-cancer mice under the influence of phytoadaptogen

Bull Exp Biol Med. 2014 Jun;157(2):258-60. doi: 10.1007/s10517-014-2539-4. Epub 2014 Jun 22.

Authors

O A Bocharova¹, E V Bocharov, R V Karpova, V A Il'enko, I V Kazeev, A Yu Baryshnikov

Affiliation

¹ N. N. Blokhin Russian Research Center of Oncology, Russian Academy of Medical Sciences, Moscow, Russia, imufarm@rambler.ru.

PMID: 24952495
DOI: 10.1007/s10517-014-2539-4

Abstract

The expression of leukocyte integrins LFA-1 and Mac-1 and cytokines IL-6 and IL-10 was studied in mice predisposed to spontaneous hepatocarcinomas. The efficacy of a phytoadaptogen in correcting these parameters was evaluated. The role of adhesive interactions between immune cells and target cells in the recovery of antitumor regulatory mechanisms was estimated.

MeSH terms

Animals
Cell Adhesion / drug effects
Hepatoblastoma / blood
Hepatoblastoma / metabolism
Interleukin-10 / blood*
Interleukin-6 / blood*
Lymphocyte Function-Associated Antigen-1 / metabolism*
Macrophage-1 Antigen / metabolism*
Mice
Plant Extracts / pharmacology*

Substances

Interleukin-6
Lymphocyte Function-Associated Antigen-1
Macrophage-1 Antigen
PM 40
Plant Extracts
Interleukin-10