RETRACTED: PKA-mediated phosphorylation of ATR promotes recruitment of XPA to UV-induced DNA damage

Mol Cell. 2014 Jun 19;54(6):999-1011. doi: 10.1016/j.molcel.2014.05.030.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the authors. An investigation by the University of Kentucky (UK) recently determined that it contains fabricated and/or falsified data committed by the lead author on the paper. The results of the investigation can be viewed at https://ori.hhs.gov/content/case-summary-jarrett-stuart-g. UK identified that there were duplications and flips of panels in three figures (Figures 7D, 7E, and S3C), and original data could not be retrieved. In Figures 7D and 7E, there are inappropriate loading controls: reuse and relabeling between Figure 7D (no UV) and Figure 7E (+ UV). In Figure S3C, the loading controls for 6-4 PP (second row down) are the same as those for XPA (fourth row down), but are flipped. In both cases, the authors could not recover the original data, since primary data were stored only on a computer associated with a Storm PhosphorImager and were lost when that computer crashed. Thus, this is considered data fabrication, and the authors are retracting the paper. The authors apologize to the scientific community for any inconveniences or challenges resulting from the publication and retraction of this manuscript. Authors Stuart Jarrett and Jillian Vanover could not be reached. The remaining authors agree to the retraction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Ataxia Telangiectasia Mutated Proteins / chemistry
  • Ataxia Telangiectasia Mutated Proteins / genetics
  • Cell Line, Tumor
  • Cyclic AMP-Dependent Protein Kinases / genetics
  • DNA Damage*
  • DNA Repair / genetics
  • DNA-Binding Proteins / genetics
  • HEK293 Cells
  • Humans
  • MCF-7 Cells
  • Mice
  • Mice, Inbred C57BL
  • Mutagenesis / radiation effects
  • Phosphorylation / radiation effects
  • Pigmentation / genetics
  • Protein Processing, Post-Translational / genetics
  • Protein Processing, Post-Translational / radiation effects
  • RNA Interference
  • RNA, Small Interfering
  • Receptor, Melanocortin, Type 1 / genetics*
  • Signal Transduction / genetics
  • Signal Transduction / radiation effects
  • Ultraviolet Rays
  • Xeroderma Pigmentosum Group A Protein / genetics
  • Xeroderma Pigmentosum Group A Protein / metabolism*

Substances

  • DNA-Binding Proteins
  • RNA, Small Interfering
  • Receptor, Melanocortin, Type 1
  • XPA protein, human
  • Xeroderma Pigmentosum Group A Protein
  • ATR protein, human
  • Ataxia Telangiectasia Mutated Proteins
  • Cyclic AMP-Dependent Protein Kinases