A stay of execution: type I interferons pardon T cells from death by natural killers

Immunity. 2014 Jun 19;40(6):861-2. doi: 10.1016/j.immuni.2014.05.009.

Abstract

In this issue of Immunity, Crouse et al., (2014) and Xu et al., (2014), show that by modulating the expression of natural killer (NK) cell receptor ligands, type I interferons protect responding T cells against culling by NK cells.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigens, Ly / immunology*
  • CD8-Positive T-Lymphocytes / immunology*
  • Cytotoxicity, Immunologic*
  • Interferon Type I / immunology*
  • Killer Cells, Natural / immunology*
  • Lymphocytic Choriomeningitis / immunology*
  • Natural Cytotoxicity Triggering Receptor 1 / immunology*
  • Receptor, Interferon alpha-beta / genetics*
  • Receptor, Interferon alpha-beta / immunology*

Substances

  • Antigens, Ly
  • Ifnar1 protein, mouse
  • Interferon Type I
  • Natural Cytotoxicity Triggering Receptor 1
  • Ncr1 protein, mouse
  • Receptor, Interferon alpha-beta