Study on the processing mechanism of traditional Chinese medicine is the key to science of processing Chinese materia medica and modernization of traditional Chinese medicine. At present, chemical and pharmacology methods are mainly used to discuss the processing principle of efficiency, attenuated, delayed or cooked with different treatment. So that the processing mechanism of Chinese herbal medicine has made breakthrough progress. With the introduction of modern science and technology, biotransformation, intestinal absorption, pharmacokinetics and metabolomics methods have been gradually applied in traditional Chinese medicine processing mechanism. This article summarizes the achievements in the processing mechanism of traditional Chinese medicine in recent years, analyses and discusses some main problems, and points out to in-depth study on absorption and metabolism, strengthening excipient processing mechanism, paying attention to the integration of multiple disciplines and data statistical analysis. Combined with years of exploration and practice, the project group proposes a new idea "traditional Chinese medicine processing mechanism based on coupled effect of chemical composition transformation and intestinal absorption barrier" , which provides reference for the study of the mechanism of traditional Chinese medicine processing.