The ins and outs of angiotensin processing within the kidney

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R487-9. doi: 10.1152/ajpregu.00177.2014. Epub 2014 Jun 18.

Abstract

The kidney is a key target organ for bioactive components of the renin-angiotensin system (RAS); however, various renal cells such as the tubular epithelium contain an intrinsic RAS. The renal RAS can be functionally divided into ANG II-AT1 receptor and ANG-(1-7)-AT7/Mas receptor arms that functionally oppose one another. The current review considers both extracellular and intracellular pathways that potentially govern the formation and metabolism of angiotensin peptides within the renal proximal tubules.

Keywords: angiotensin II; angiotensin-(1–7); fetal programming; kidney; metabolism; peptidase.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Angiotensin I / physiology
  • Angiotensins / metabolism*
  • Animals
  • Humans
  • Kidney Tubules, Proximal / metabolism*
  • Peptide Fragments / physiology
  • Receptor, Angiotensin, Type 1 / physiology
  • Renin-Angiotensin System / physiology

Substances

  • Angiotensins
  • Peptide Fragments
  • Receptor, Angiotensin, Type 1
  • Angiotensin I
  • angiotensin I (1-7)