Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in-vivo dual-modality PET/MR imaging

Adv Mater. 2014 Aug 13;26(30):5119-23. doi: 10.1002/adma.201401372. Epub 2014 Jun 18.

Abstract

Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of (69) Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful utilization of a (69) Ge-based agent for PET/MR imaging.

Keywords: chelator-free radiolabeling; germanium-69; iron oxide nanoparticles; multimodality imaging; positron emission tomography/magnetic resonance (PET/MR) imaging.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Contrast Media / chemical synthesis
  • Contrast Media / pharmacokinetics
  • Feasibility Studies
  • Germanium* / chemistry
  • Germanium* / pharmacokinetics
  • Isotope Labeling / methods
  • Magnetic Resonance Imaging / methods*
  • Magnetite Nanoparticles* / chemistry
  • Mice
  • Mice, Inbred BALB C
  • Multimodal Imaging / methods*
  • Positron-Emission Tomography / methods*
  • Radioisotopes* / chemistry
  • Radioisotopes* / pharmacokinetics
  • Staining and Labeling / methods
  • Whole Body Imaging / methods*

Substances

  • Contrast Media
  • Magnetite Nanoparticles
  • Radioisotopes
  • Germanium