Pd(II)-Catalyzed arylation of unactivated methylene C(sp3)-H bonds with aryl halides using a removable auxiliary

Chem Commun (Camb). 2014 Aug 7;50(61):8353-5. doi: 10.1039/c4cc03615h.

Abstract

A Pd(II)-catalyzed arylation of methylene C(sp(3))-H bonds in aliphatic amides directed by our newly developed PIP directing group with aryl iodides/bromides has been achieved. Arylation occurs efficiently with a broad range of aryl halides and amides.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemistry
  • Bromides / chemistry
  • Carbon / chemistry
  • Catalysis
  • Hydrogen / chemistry
  • Iodides / chemistry
  • Palladium / chemistry*

Substances

  • Amides
  • Bromides
  • Iodides
  • Palladium
  • Carbon
  • Hydrogen