Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. I. Taxonomy of the producing strain, fermentation, isolation and biological properties

M Nakagawa; Y H Hsu; A Hirota; S Shima; M Nakayama

doi:10.7164/antibiotics.42.218

Myrocin C, a new diterpene antitumor antibiotic from Myrothecium verrucaria. I. Taxonomy of the producing strain, fermentation, isolation and biological properties

J Antibiot (Tokyo). 1989 Feb;42(2):218-22. doi: 10.7164/antibiotics.42.218.

Authors

M Nakagawa¹, Y H Hsu, A Hirota, S Shima, M Nakayama

Affiliation

¹ Department of Agricultural Chemistry, College of Agriculture, University of Osaka Prefecture, Japan.

PMID: 2494145
DOI: 10.7164/antibiotics.42.218

Abstract

A new diterpene antitumor antibiotic, myrocin C, has been isolated from the culture filtrate of a soil fungus, Myrothecium verrucaria strain No. 55. The antibiotic was effective against Gram-positive bacteria, fungi and yeasts, and prolonged the life span of mice bearing Ehrlich ascites carcinoma.

Publication types

Comparative Study

MeSH terms

Animals
Antibiotics, Antineoplastic / isolation & purification*
Antibiotics, Antineoplastic / pharmacology
Carcinoma, Ehrlich Tumor / pathology
Cell Line / drug effects
Diterpenes / isolation & purification
Diterpenes / pharmacology
Female
Fermentation
Fungi / analysis*
Mice
Microbial Sensitivity Tests
Mitomycin
Mitomycins / pharmacology
Soil Microbiology

Substances

Antibiotics, Antineoplastic
Diterpenes
Mitomycins
myrocin C
Mitomycin