Abstract
Three new coumarins and 13 known compounds were isolated from the stem bark of Toddalia asiatica. Compounds 1, 3, 8, and 9 showed cytotoxicity against the NCI-H187 cell line with IC50 values ranging from 6 to 9 µg/mL. Compounds 4 and 9 exhibited cytotoxicity against the MCF-7 cell line with IC50 values of 3.17 and 9.79 µg/mL, respectively. Compound 9 also displayed cytotoxic activity against KB cells with an IC50 value of 8.63 µg/mL. In addition, compound 14 showed antimalarial activity against Plasmodium falciparum with an IC50 value of 3.66 µg/mL. Compounds 5, 9, and 16 exhibited antituberculosis activity against Mycobacterium tuberculosis with MIC values of 50, 50, and 25 µg/mL, respectively.
Georg Thieme Verlag KG Stuttgart · New York.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antimalarials / chemistry
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Antimalarials / isolation & purification
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Antimalarials / pharmacology*
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification
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Antitubercular Agents / pharmacology*
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Cell Line, Tumor
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Cell Survival / drug effects
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Chlorocebus aethiops
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Coumarins / chemistry
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Coumarins / isolation & purification
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Coumarins / pharmacology*
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Mycobacterium tuberculosis / drug effects
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plasmodium falciparum / drug effects
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Rutaceae / chemistry*
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Vero Cells
Substances
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Antimalarials
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Antitubercular Agents
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Coumarins
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Plant Extracts