Predictors of mesorectal fascia invasion after gadolinium injection in rectal carcinoma after neoadjuvant therapy

Clin Imaging. 2014 Sep-Oct;38(5):698-703. doi: 10.1016/j.clinimag.2014.05.003. Epub 2014 May 16.

Abstract

Objective: To assess spectral presaturation inversion-recovery MRI sequence with gadolinium to identify predictors of mesorectal fascia (MRF) invasion in patients with locally advanced rectal carcinoma after neoadjuvant therapy.

Materials and methods: Sixty-five patients underwent neoadjuvant concomitant radiation and chemotherapy and surgery. Magnetic resonance images were assessed by two radiologists.

Results: Linear (odds ratio, 95% confidence intervals: 19.33, 1.98-188.6) and reticular strands (odds ratio, 95% confidence intervals: 9.75, 1.45-67.77) reaching the MRF are predictors of MRF invasion.

Conclusion: Linear or reticular mesorectal strands reaching the MRF detected at contrast-enhanced MRI represent a predictor of MRF invasion.

Keywords: Magnetic resonance imaging; Mesorectal fascia; Neoadjuvant therapy; Rectal cancer.

MeSH terms

  • Aged
  • Aged, 80 and over
  • Contrast Media / administration & dosage
  • Fascia / pathology*
  • Female
  • Follow-Up Studies
  • Gadolinium / administration & dosage
  • Heterocyclic Compounds / administration & dosage*
  • Humans
  • Injections, Intralesional
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Neoadjuvant Therapy
  • Neoplasm Invasiveness
  • Neoplasm Staging / methods*
  • Organometallic Compounds / administration & dosage*
  • Predictive Value of Tests
  • Rectal Neoplasms / diagnosis*
  • Rectal Neoplasms / therapy
  • Reproducibility of Results
  • Retrospective Studies

Substances

  • Contrast Media
  • Heterocyclic Compounds
  • Organometallic Compounds
  • gadoteridol
  • Gadolinium