Abstract
Thirty-three children with leukemia who had neutropenia and fever were randomized to receive cefataxim and amikacin, versus the same antibiotics plus intravenous gammaglobulin (i.v. IgG). Duration of neutropenia, hospitalization and the interruption of chemotherapy were not different in the two groups; however, duration of fever was significantly shorter in the i.v. IgG group.
Publication types
-
Clinical Trial
-
Comparative Study
-
Randomized Controlled Trial
MeSH terms
-
Agranulocytosis / complications*
-
Amikacin / administration & dosage*
-
Amikacin / therapeutic use
-
Antineoplastic Agents / adverse effects
-
Cefotaxime / administration & dosage*
-
Cefotaxime / therapeutic use
-
Child
-
Drug Therapy, Combination / therapeutic use
-
Fever / chemically induced
-
Fever / complications*
-
Humans
-
Immunoglobulin G / administration & dosage*
-
Immunoglobulin G / therapeutic use
-
Immunoglobulins, Intravenous
-
Infection Control
-
Leukemia, Myeloid, Acute / complications*
-
Leukemia, Myeloid, Acute / drug therapy
-
Neutropenia / chemically induced
-
Neutropenia / complications*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
-
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy
Substances
-
Antineoplastic Agents
-
Immunoglobulin G
-
Immunoglobulins, Intravenous
-
Amikacin
-
Cefotaxime