New laboratory markers for the management of rheumatoid arthritis patients

Clin Chem Lab Med. 2014 Dec;52(12):1729-37. doi: 10.1515/cclm-2014-0383.

Abstract

Rheumatoid arthritis, the most prominent of systemic autoimmune rheumatic diseases, represents an important social health problem. Recent insights into the immunopathogenic mechanism of this complex and multiform illness might open new perspectives for a more appropriate laboratory approach. In this review we focus on the most relevant pathogenetic mechanism; indicating the laboratory biomarkers specifically linked to early diagnosis, prognosis, evolutive aspects of the disease, and therapeutic efficacy. Evidence based on laboratory medicine could provide the best outcome for patients.

Publication types

  • Review

MeSH terms

  • Arthritis, Rheumatoid / diagnosis*
  • Arthritis, Rheumatoid / pathology
  • Biomarkers / metabolism*
  • Cytokines / genetics
  • Cytokines / metabolism
  • HLA-DRB1 Chains / genetics
  • HLA-DRB1 Chains / metabolism
  • Humans
  • Killer Cells, Natural / immunology
  • Killer Cells, Natural / metabolism
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22 / genetics
  • Receptors, Cytokine / genetics
  • Receptors, Cytokine / metabolism
  • Transcription Factors / genetics
  • Transcription Factors / metabolism

Substances

  • Biomarkers
  • Cytokines
  • HLA-DRB1 Chains
  • Receptors, Cytokine
  • Transcription Factors
  • PTPN22 protein, human
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22