A novel Affibody bioconjugate for dual-modality imaging of ovarian cancer

Chem Commun (Camb). 2014 Nov 4;50(85):12832-5. doi: 10.1039/c4cc03454f.

Abstract

An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cell Line
  • Chelating Agents* / chemistry
  • Dendrimers* / chemistry
  • Female
  • Fluorescent Dyes* / chemistry
  • Humans
  • Immunoconjugates*
  • Mice
  • Mice, Nude
  • Models, Molecular
  • Optical Imaging / methods
  • Ovarian Neoplasms / diagnosis*
  • Ovarian Neoplasms / pathology
  • Ovary / pathology*
  • Polyamines* / chemistry
  • Positron-Emission Tomography / methods

Substances

  • Chelating Agents
  • Dendrimers
  • Fluorescent Dyes
  • Immunoconjugates
  • Poly(amidoamine)
  • Polyamines