Abstract
An Affibody based dual imaging probe (PET and optical imaging) has been successfully developed. Dendrimer PAMAM G0 was used as a platform to assemble an NIRF dye, a metal chelator, and Affibody for dual modality imaging of ovarian cancer. Excellent tumor imaging quality was achieved in both modalities in the living tumor mice models.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Cell Line
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Chelating Agents* / chemistry
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Dendrimers* / chemistry
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Female
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Fluorescent Dyes* / chemistry
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Humans
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Immunoconjugates*
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Mice
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Mice, Nude
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Models, Molecular
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Optical Imaging / methods
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Ovarian Neoplasms / diagnosis*
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Ovarian Neoplasms / pathology
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Ovary / pathology*
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Polyamines* / chemistry
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Positron-Emission Tomography / methods
Substances
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Chelating Agents
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Dendrimers
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Fluorescent Dyes
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Immunoconjugates
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Poly(amidoamine)
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Polyamines