AKAP5 keeps L-type channels and NFAT on their toes

Cell Rep. 2014 Jun 12;7(5):1341-1342. doi: 10.1016/j.celrep.2014.05.052.

Abstract

In this issue of Cell Reports, Murphy et al. and Dittmer et al. present exciting new insight into the regulation of Ca2+ influx via the L-type Ca2+ channel Cav1.2 and how increased Ca2+ influx translates into localized activation of the nuclear transcription factor NFAT upon depolarization in neurons.

Publication types

  • Comment

MeSH terms

  • A Kinase Anchor Proteins / metabolism*
  • Animals
  • Calcineurin / metabolism*
  • Calcium / metabolism*
  • Calcium Channels, L-Type / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Dendritic Spines / metabolism*
  • Humans
  • NFATC Transcription Factors / metabolism*
  • Neurons / metabolism*
  • Signal Transduction*
  • Transcriptional Activation*

Substances

  • A Kinase Anchor Proteins
  • Calcium Channels, L-Type
  • NFATC Transcription Factors
  • Cyclic AMP-Dependent Protein Kinases
  • Calcineurin
  • Calcium