Abstract
In this issue of Cell Reports, Murphy et al. and Dittmer et al. present exciting new insight into the regulation of Ca2+ influx via the L-type Ca2+ channel Cav1.2 and how increased Ca2+ influx translates into localized activation of the nuclear transcription factor NFAT upon depolarization in neurons.
Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.
MeSH terms
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A Kinase Anchor Proteins / metabolism*
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Animals
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Calcineurin / metabolism*
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Calcium / metabolism*
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Calcium Channels, L-Type / metabolism*
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Cyclic AMP-Dependent Protein Kinases / metabolism*
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Dendritic Spines / metabolism*
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Humans
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NFATC Transcription Factors / metabolism*
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Neurons / metabolism*
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Signal Transduction*
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Transcriptional Activation*
Substances
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A Kinase Anchor Proteins
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Calcium Channels, L-Type
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NFATC Transcription Factors
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Cyclic AMP-Dependent Protein Kinases
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Calcineurin
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Calcium