Abstract
Here we describe the screening via Dynamic Deconvolution of DCLs of inhibitors (CAIs) and activators (CAAs) of hCA I. The inhibitory effects dominate over the activating ones, while the CAAs may be identified in the absence of CAIs.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbonic Anhydrase I / antagonists & inhibitors*
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Carbonic Anhydrase I / metabolism*
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Carbonic Anhydrase Inhibitors / chemistry
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Carbonic Anhydrase Inhibitors / pharmacology*
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Enzyme Activation / drug effects
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Humans
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Molecular Structure
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Structure-Activity Relationship
Substances
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Carbonic Anhydrase Inhibitors
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Carbonic Anhydrase I