Abstract
The objective was an assessment of the impact of Leonurus cardiaca L. extract (LCE) and ursolic acid (UA) on the adhesive properties of Staphylococus aureus NCTC 8325 strain, expressing virulence factors important in the pathogenesis of infective endocarditis. The adhesion and biofilm formation of bacteria cultured in the presence of subinhibitory concentrations of LCE or UA on the abiotic surface or covered with fibrinogen, fibronectin or collagen, were evaluated. Inhibitory effects of LCE and UA on staphylococcal adherence to both types of surface were demonstrated. This, in the case of UA, resulted in a significant reduction of biofilm formation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Bacterial Adhesion / drug effects
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Biofilms / drug effects*
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Biofilms / growth & development
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Collagen / chemistry
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Endocarditis / microbiology
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Fibrinogen / chemistry
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Fibronectins / chemistry
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Humans
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Leonurus / chemistry*
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Microbial Sensitivity Tests
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / isolation & purification
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Staphylococcus aureus / physiology
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Triterpenes / pharmacology*
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Ursolic Acid
Substances
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Anti-Bacterial Agents
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Fibronectins
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Plant Extracts
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Triterpenes
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Fibrinogen
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Collagen