Hsp90 picks PIKKs via R2TP and Tel2

Cara K Vaughan

doi:10.1016/j.str.2014.05.012

Hsp90 picks PIKKs via R2TP and Tel2

Structure. 2014 Jun 10;22(6):799-800. doi: 10.1016/j.str.2014.05.012.

Author

Cara K Vaughan¹

Affiliation

¹ Institute of Structural and Molecular Biology, Birkbeck College and University College London, Malet Street, London WC1E 7HX, UK. Electronic address: c.vaughan@mail.cryst.bbk.ac.uk.

Abstract

Phosphatidylinositol-3 kinase-like kinases (PIKKs) are dependent on Hsp90 for their activation via the R2TP complex and Tel2. In this issue of Structure, Pal and colleagues present the molecular mechanism by which PIKKs are recruited to Hsp90.

Publication types

Comment

MeSH terms

HSP90 Heat-Shock Proteins / chemistry*
HSP90 Heat-Shock Proteins / metabolism*
Nuclear Proteins / chemistry*
Nuclear Proteins / metabolism*
Saccharomyces cerevisiae Proteins / chemistry*
Saccharomyces cerevisiae Proteins / metabolism*
Telomere-Binding Proteins / chemistry*
Telomere-Binding Proteins / metabolism*

Substances

HSP82 protein, S cerevisiae
HSP90 Heat-Shock Proteins
Nuclear Proteins
PIH1 protein, S cerevisiae
Saccharomyces cerevisiae Proteins
Tel2 protein, S cerevisiae
Telomere-Binding Proteins