Close flanking markers for neurofibromatosis type I (NF1)

M Upadhyaya; M Sarfarazi; S M Huson; W Broadhead; A Fryer; P S Harper

Close flanking markers for neurofibromatosis type I (NF1)

Am J Hum Genet. 1989 Jan;44(1):41-7.

Authors

M Upadhyaya¹, M Sarfarazi, S M Huson, W Broadhead, A Fryer, P S Harper

Affiliation

¹ Institute of Medical Genetics, University of Wales College of Medicine, Cardiff, United Kingdom.

PMID: 2491781
PMCID: PMC1715482

Abstract

A genetic linkage study with 16 polymorphic DNA markers spanning the region 17p11-17q24 in 22 NF1 families is presented. Close linkage between NF1 and eight pericentromeric markers (HHH202, EW206, CRI-L946, EW203, EW301, FG2, p17H8, and CRI-L581) has been found, probe HHH202 being the closest marker to NF1. Genetic heterogeneity has been excluded. The study of multiply informative meioses suggests that the probes HHH202 and RW206 are flanking markers for NF1. The most likely order on the basis of multiply informative meioses and multipoint mapping is pter-pA10.41-EW301-cen-HHH202-NF1-EW206-++ +EW207-qter.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Mapping*
Chromosomes, Human, Pair 17*
Female
Genetic Linkage
Genetic Markers*
Humans
Male
Neurofibromatosis 1 / genetics*
Pedigree
Recombination, Genetic

Substances

Genetic Markers