Background: In this study, we aimed to determine the extent of possible genetic influence on cardio-metabolic risk factors, evaluate the familial aggregation of MetS and estimate the siblings' recurrence risk ratios in a Tehrani population.
Methods: In a cross-sectional observational study, we made anthropometric, blood pressure, and biochemical measurements in each member of 566 Tehrani nuclear families.
Results: Grandmothers had the highest incidence of atherosclerotic risk factors. Four factors were found which accounted for 77.7% of the overall variance. Recurrence risk ratio among siblings was 5.61 (95% confidence interval [CI]: 3.15-9.97). The adjusted odds ratio (OR) of proband's MetS status was 1.33 (95% CI: 1.06-1.67). The adjusted OR for the four factors to predict MetS were all significant, with obesity having the highest risk (OR: 7.50, CI: 5.91-9.52), followed by dyslipidemia/hyperglycemia (OR: 4.86, CI: 4.03-5.87), and blood pressure (OR: 4.20, CI: 3.51-5.02).
Conclusion: A high risk of MetS (five-fold) was found in siblings with MetS proband. Moreover, findings confirm the importance of obesity for the aggregation of MetS by nearly seven-fold in the study population.