Synthesis, characterization, biological and catalytic applications of transition metal complexes derived from Schiff base

A Bushra Begum; N D Rekha; B C Vasantha Kumar; V Lakshmi Ranganatha; Shaukath Ara Khanum

doi:10.1016/j.bmcl.2014.05.046

Synthesis, characterization, biological and catalytic applications of transition metal complexes derived from Schiff base

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3559-64. doi: 10.1016/j.bmcl.2014.05.046. Epub 2014 May 23.

Authors

A Bushra Begum¹, N D Rekha², B C Vasantha Kumar³, V Lakshmi Ranganatha⁴, Shaukath Ara Khanum⁵

Affiliations

¹ Department of Chemistry, Yuvaraj's College (Autonomous), University of Mysore, Mysore 570 005, Karnataka, India; Department of Chemistry, D.Banumaiah's P U Science College, Mysore 570 024, Karnataka, India.
² Department of Studies in Biotechnology, JSS College of Arts, Commerce and Science, Mysore, India.
³ Department of Chemistry, University of Mysore, Mysore, India.
⁴ Department of Chemistry, Yuvaraj's College (Autonomous), University of Mysore, Mysore 570 005, Karnataka, India.
⁵ Department of Chemistry, Yuvaraj's College (Autonomous), University of Mysore, Mysore 570 005, Karnataka, India. Electronic address: shaukathara@yahoo.co.in.

PMID: 24915881
DOI: 10.1016/j.bmcl.2014.05.046

Abstract

A novel series of Cu(II), Ni(II), Zn(II), Co(II), and Cd(II) complexes have been synthesized from the Schiff base. Structural features were determined by analytical and spectral techniques like IR, (1)H NMR, UV-vis, elemental analysis, molar electric conductibility, magnetic susceptibility and thermal studies. The complexes are found to be soluble in dimethylformamide and dimethylsulfoxide. Molar conductance values in dimethylformamide indicate the non-electrolytic nature of the complexes. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied. There is significant binding of DNA in lanes 2, 3, and 5. Lanes 4 and 6 are showing more florescence when compared to the control indicating that these molecules are strongly bound to the DNA by inserting themselves between the two stacked base pairs and exhibiting their original property of fluorescence. Angiogenesis study has revealed that the compounds B-2, B-4 and B-5 have potent antitumor efficacy and activation of antiangiogenesis could be one of the possible underlying mechanisms of tumor inhibition.

Keywords: Angiogenesis; Binding/cleavage of DNA; Schiff base ligand.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors / chemical synthesis
Angiogenesis Inhibitors / chemistry
Angiogenesis Inhibitors / pharmacology*
Animals
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Catalysis
Cattle
Cell Proliferation / drug effects
DNA / chemistry
DNA / drug effects*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Fluorescence
Molecular Structure
Neoplasms / drug therapy*
Neoplasms / pathology
Neovascularization, Pathologic / drug therapy*
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry
Organometallic Compounds / pharmacology*
Schiff Bases / chemistry
Structure-Activity Relationship
Transition Elements / chemistry

Substances

Angiogenesis Inhibitors
Antineoplastic Agents
Organometallic Compounds
Schiff Bases
Transition Elements
DNA
calf thymus DNA