The prediction of complicated Clostridium difficile infections in children

Sarah Tschudin-Sutter; Pranita D Tamma; Aaron M Milstone; Trish M Perl

doi:10.1086/676874

The prediction of complicated Clostridium difficile infections in children

Infect Control Hosp Epidemiol. 2014 Jul;35(7):901-3. doi: 10.1086/676874. Epub 2014 May 20.

Authors

Sarah Tschudin-Sutter¹, Pranita D Tamma, Aaron M Milstone, Trish M Perl

Affiliation

¹ Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland.

PMID: 24915226
DOI: 10.1086/676874

Abstract

We validated proposed definitions for severe Clostridium difficile infection (CDI) in adults for prediction of complicated CDI in children. Complicated CDI occurred in 9 of 202 cases. Definitions for severe CDI in adults showed poor measures for discrimination of complicated CDI in children, which calls into question the usefulness of such definitions in pediatric cohorts.

Publication types

Research Support, Non-U.S. Gov't
Validation Study

MeSH terms

Adolescent
Child
Child, Preschool
Clostridioides difficile / isolation & purification*
Clostridium Infections / classification
Clostridium Infections / complications
Clostridium Infections / diagnosis*
Female
Hospitalization
Humans
Infant
Male
Predictive Value of Tests
Retrospective Studies
Severity of Illness Index
Young Adult