Telomere length regulation in budding yeasts

Alexander N Malyavko; Yuliya Y Parfenova; Maria I Zvereva; Olga A Dontsova

doi:10.1016/j.febslet.2014.05.049

Telomere length regulation in budding yeasts

FEBS Lett. 2014 Aug 1;588(15):2530-6. doi: 10.1016/j.febslet.2014.05.049. Epub 2014 Jun 7.

Authors

Alexander N Malyavko¹, Yuliya Y Parfenova¹, Maria I Zvereva¹, Olga A Dontsova²

Affiliations

¹ Faculty of Chemistry, Lomonosov Moscow State University, 119999 Moscow, Russia; Belozersky Institute, Moscow State University, Leninskie Gory 1, Bldg. 40, 119991 Moscow, Russia.
² Faculty of Chemistry, Lomonosov Moscow State University, 119999 Moscow, Russia; Belozersky Institute, Moscow State University, Leninskie Gory 1, Bldg. 40, 119991 Moscow, Russia. Electronic address: dontsova@genebee.msu.ru.

PMID: 24914478
DOI: 10.1016/j.febslet.2014.05.049

Abstract

Telomeres are the nucleoprotein caps of chromosomes. Their length must be tightly regulated in order to maintain the stability of the genome. This is achieved by the intricate network of interactions between different proteins and protein-RNA complexes. Different organisms use various mechanisms for telomere length homeostasis. However, details of these mechanisms are not yet completely understood. In this review we have summarized our latest achievements in the understanding of telomere length regulation in budding yeasts.

Keywords: Budding yeast; Telomerase; Telomere.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Chromosomes, Fungal / genetics
Saccharomyces cerevisiae / genetics*
Saccharomyces cerevisiae / metabolism
Telomere Homeostasis*