Abstract
Highly enantioselective iridium-catalyzed hydrogenation of pyrrolo[1,2-a]pyrazinium salts has been achieved, providing a direct access to chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives with up to 95% ee. The key feature of the reaction is the addition of cesium carbonate, which increases the conversion and prohibits the racemization pathway of products.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Carbonates / chemistry
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Catalysis
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Cesium / chemistry
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Hydrogenation
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Iridium / chemistry*
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Molecular Structure
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Pyrazines / chemical synthesis
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Pyrazines / chemistry*
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Pyrroles / chemical synthesis
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Pyrroles / chemistry*
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Salts
Substances
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Carbonates
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Pyrazines
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Pyrroles
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Salts
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Cesium
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Iridium
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cesium carbonate