Inhibitory role of polyunsaturated fatty acids on lysophosphatidic acid-induced cancer cell migration and adhesion

FEBS Lett. 2014 Aug 25;588(17):2971-7. doi: 10.1016/j.febslet.2014.05.052. Epub 2014 Jun 6.

Abstract

Polyunsaturated fatty acids (PUFAs) have important pharmacological effects on mammalian cells. Here, we show that carboxyl group-containing PUFAs inhibit lysophosphatidic acid (LPA)-induced focal adhesion formation, thereby inhibiting migration and adhesion. Carboxyl group-containing PUFAs inhibit LPA-induced calcium mobilization, whereas ethyl ester-group containing PUFAs have no effect. In addition, carboxyl group-containing PUFAs functionally inhibit LPA-dependent RhoA activation. Given these results, we suggest that PUFAs may inhibit LPA-induced calcium/RhoA signaling pathways leading to focal adhesion formation. Carboxyl group-containing PUFAs may have a functional role in this regulatory mechanism.

Keywords: Adhesion; Calcium mobilization; Lysophosphatidic acid; Migration; Vinculin; α-Linolenic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2 / metabolism
  • Calmodulin / metabolism
  • Cell Adhesion / drug effects
  • Cell Line, Tumor
  • Cell Movement / drug effects*
  • Fatty Acids, Unsaturated / pharmacology*
  • Focal Adhesions / drug effects
  • Focal Adhesions / metabolism
  • Humans
  • Lysophospholipids / adverse effects*
  • Signal Transduction / drug effects

Substances

  • Calmodulin
  • Fatty Acids, Unsaturated
  • Lysophospholipids
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • lysophosphatidic acid
  • Calcium