Abstract
In patients with acute poisoning amine salt herbicide 2,4-D develops oxidative stress with simultaneous inhibition of intracellular and extracellular antioxidant factors. These changes are more pronounced with neurological disorders that occur in conjunction with a toxic damage of liver or heart. The inclusion of a comprehensive detoxification therapy alpha-lipoic acid not only promotes a more pronounced therapeutic effect but also an earlier recourse cytolytic syndrome, a marked recovery of levels of malondialdehyde and indices of antioxidant system (superoxide dismutase and ceruloplasmin) than for patients in the comparison group.
MeSH terms
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2,4-Dichlorophenoxyacetic Acid / poisoning*
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Acute Disease
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Adult
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Agricultural Workers' Diseases* / chemically induced
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Agricultural Workers' Diseases* / drug therapy
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Agricultural Workers' Diseases* / metabolism
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Antioxidants / administration & dosage
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Antioxidants / therapeutic use*
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Drug Therapy, Combination
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Female
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Heart Function Tests
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Herbicides / poisoning*
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Humans
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Liver Function Tests
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Middle Aged
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Occupational Exposure / adverse effects
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Occupational Health
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Oxidative Stress / drug effects*
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Thioctic Acid / administration & dosage
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Thioctic Acid / therapeutic use*
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Treatment Outcome
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Young Adult
Substances
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Antioxidants
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Herbicides
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2,4-Dichlorophenoxyacetic Acid
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Thioctic Acid