Abstract
Systemic lupus erythematosus is a prototypic but heterogeneous autoimmune disease. The major clinical symptoms and signs are reviewed, as well as the main immunological abnormalities. Emphasis is put on the role of long-lived autoimmune plasma cells, not affected by current immunosuppressants and biologics, which are responsible for refractoriness and relapses.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
MeSH terms
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Autoantibodies / immunology
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Autoimmune Diseases / diagnosis
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Autoimmune Diseases / immunology
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Biological Products / therapeutic use
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Humans
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Immunosuppressive Agents / therapeutic use
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Lupus Erythematosus, Systemic / complications
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Lupus Erythematosus, Systemic / diagnosis*
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Lupus Erythematosus, Systemic / immunology
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Plasma Cells / immunology
Substances
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Autoantibodies
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Biological Products
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Immunosuppressive Agents